Table 3

Risk factors of GSD incidence by sex. MAUCO 2015–2023

	Total	New GBD	Person-years	Incidence 1000/p-y	Age-adjusted HR (95% CI)
A. Women	1495	139	7318.71	18.9
Age
<45 years	192	23	710.86	32.36	Ref
45–54 years	421	43	1233.30	34.87	1.25 (0.75 to 2.07)
55–64	537	43	1338.23	32.13	1.46 (0.87 to 2.44)
65+	345	30	877.13	34.20	1.73 (0.98 to 3.03)
Schooling
+13 years	175	20	486.70	41.09	Ref
<4 years	159	14	432.28	32.87	0.83 (0.42 to 1.65)
4–8 years	549	53	1480.74	35.79	0.94 (0.56 to 1.59)
9–12 years	612	52	1759.80	29.55	0.77 (0.46 to 1.31)
Normal waist circumference	358	22	1030.48	21.35	Ref
Risk waist circumference*	1135	117	3122.45	37.47	1.84 (1.16 to 2.90)
HDL cholesterol
≥50	580	49	1611.44	30.41	Ref
<50	914	90	2543.95	35.38	1.19 (0.84 to 1.69)
Diet Med Score
<6	842	70	2318.06	30.20	Ref
≥6	530	49	1511.91	32.41	0.97 (0.67 to 1.40)
Children
<3	796	73	2249.34	32.45	Ref
≥3	699	66	1910.19	34.55	1.11 (0.79 to 1.55)
Family history GBC
No	1461	135	4060.51	33.25	Ref
Yes	34	4	99.02	40.40	1.21 (0.45 to 3.28)
B. Men	789	59	4087.56	14,4
Age
<45 years	95	3	398.12	7.54	Ref
45–54 years	211	15	679.69	22.07	3.18 (0.92 to 11.02)
55–64	293	17	901.12	18.87	2.85 (0.83 to 9.77)
65+*	190	24	555.86	43.18	8.94 (2.65 to 30.12)
Schooling
+13 years	89	3	297.27	10.09	Ref
<4 years	84	4	261.20	15.31	1.02 (0.22 to 4.61)
4–8 years	315	30	980.43	30.6	2.25 (0.68 to 7.45)
9–12 years	301	22	995.89	22.09	1.99 (0.59 to 6.67)
Normal waist circumference	441	28	1454.1	19.26	Ref
Risk waist circumference	346	31	1076,49	28.80	1.37 (0.81 to 2.30)
HDL cholesterol
≥40	478	27	1538.89	17.55	Ref
<40*	307	31	982.94	31.54	1.89 (1.12 to 3.20)
Diet Med Score
<6	564	44	1849.47	23.79	Ref
≥6	158	12	495.7	24.21	1.09 (0.58 to 2.08)
Family history GBC
No	777	57	2509.05	22.72	Ref
Yes*	12	2	25.73	77.72	6.02 (1.42 to 25.5)

An HR from multiple Cox extended regression, all variables included in the model.
*p:<0.05
GBC, gallbladder cancer; GBD, gallbladder disease; Med, Mediterranean; p-y, person-years.